NAFLD和NASH:病因,目标和新兴疗法
Shulin Wei1, Li Wang2, Paul C Evans3
1School of Life Sciences, Jilin University, Changchun, China; Department of Endocrinology, Institute of Endocrine and Metabolic Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Clinical Research Hospital of Chinese Academy of Sciences (Hefei), University of Science and Technology of China, Hefei, China.
非酒精性脂肪性肝病 (NAFLD) 和非酒精性脂肪性肝炎 (NASH) 的治疗方法正在进步. 新的研究探讨了纤维细胞生长因子21 (FGF21) 类似物和甲状腺激素受体-β (THRβ) 激动剂对肝脏健康的影响.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 药理学 药理学 是一个学科.
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 和非酒精性脂肪性肝炎 (NASH) 是一个日益严重的全球健康问题,具有重大的社会经济影响.
- 目前对NAFLD/NASH分子机制的理解尚不完整,缺乏经批准的药物治疗方法.
- 近年来,在了解NAFLD/NASH病理机制和潜在治疗方法方面取得了重大进展.
研究的目的:
- 审查了解NAFLD和NASH病理机制的最新进展.
- 讨论针对肝脏脂肪含量,NASH解决和纤维化回归的新兴药物疗法.
- 在NAFLD和NASH中概述未来的研究方向.
主要方法:
- 关于NAFLD和NASH的最新科学文献的综述.
- 对研究纤维细胞生长因子21 (FGF21) 类似物 (如 pegozafermin) 的研究分析.
- 对甲状腺激素受体-β (THRβ) 激动剂 (例如,resmetriom) 的研究评估.
主要成果:
- 纤维细胞生长因子21 (FGF21) 的类似物在降低肝脏脂肪含量方面显示出有前途.
- 甲状腺激素受体-β (THRβ) 激动剂正在研究NASH解决和纤维化回归.
- 进展突出了NAFLD和NASH的潜在治疗目标.
结论:
- 新兴的治疗方法,如皮戈扎费明和复合体,为NAFLD/NASH患者提供了新的希望.
- 未来的研究应该集中在组合疗法,有机体和先进的人性化小鼠模型上.
- 对分子机制的持续研究对于开发有效的NAFLD和NASH治疗方法至关重要.
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