斋月禁食的新陈代谢和相关的慢性疾病风险
Rami Al-Jafar1, Rui Climaco Pinto2, Paul Elliott3
1Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Data Services, Lean Business Services, Riyadh, Saudi Arabia.
The American journal of clinical nutrition
|February 1, 2024
概括
斋月禁食对新陈代谢有积极的影响,并可能在短期内降低某些慢性疾病 (如肺癌,结肠直肠癌和乳腺癌) 的风险. 需要进一步研究长期影响.
科学领域:
- 代谢学 代谢学 代谢学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 斋月禁食涉及显著的生活方式变化,促使对其代谢和健康影响进行调查.
- 代谢物,作为代谢过程的关键指标,对于理解这些变化至关重要.
- 伦敦斋月研究 (LORANS) 调查了斋月对代谢概况的影响.
研究的目的:
- 检查斋月禁食对个人的新陈代谢概况的影响.
- 评估斋月禁食与患慢性疾病的风险之间的关联.
主要方法:
- 观察性研究 (LORANS) 涉及72名参与者,在斋月前后收集血液样本.
- 使用核磁共振光谱分析代谢物变化的代谢体概况.
- 用英国生物库数据 (117,981名参与者) 和LORANS.评估来生成7种慢性疾病的代谢得分.
主要成果:
- 斋月禁食改变了14种代谢物,包括炎症标记物,氨基酸,糖解相关代谢物,体,甘油三和脂蛋白子类,独立于身体组成的变化.
- 肺癌,结肠直肠癌和乳腺癌的代谢得分在LORANS参与者中,在斋月之后显著下降.
- 这些发现表明,与斋月禁食相关的短期代谢转变是有利的.
结论:
- 斋月禁食与与慢性疾病风险相关的有益的短期代谢变化有关.
- 建议进行进一步的大规模研究,进行更长的随访和临床结果,以验证这些发现.
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