暂时肠道微生物群的变化和与饮食模式的关联:从为期一年的观察性饮食,癌症和健康 - 下一代MAX研究
Agnetha L Rostgaard-Hansen1, Anders Esberg2, Johan Dicksved3
1Division of Food and Nutrition Science, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden; Department of Diet, Cancer, and Health, Danish Cancer Institute, Copenhagen, Denmark.
The American journal of clinical nutrition
|February 1, 2024
概括
在许多个体中,肠道微生物群的组成在一年内相对稳定,因此可以进行健康研究. 富含植物的饮食,包括北欧和地中海模式,与有益的肠道细菌有关.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 人类肠道微生物组
背景情况:
- 了解肠道微生物群的时间变化对于饮食和健康结果研究至关重要.
- 植物性饮食与降低发病率和死亡率有关,可能是通过有利地改变肠道微生物群.
研究的目的:
- 在丹麦人口中评估一年内肠道微生物群的变异性.
- 调查坚持饮食指数和肠道微生物群组成之间的关联.
主要方法:
- 分析DCH-NG MAX研究中444名参与者的便样本中的16S核糖体核糖核酸基因测序.
- 通过24小时回忆收集的饮食数据;计算了饮食指数 (北欧,地中海,植物性).
- 用于评估时间微生物变异性的类内相关系数 (ICC);用于饮食-微生物群关联的线性回归.
主要成果:
- 在234个属中,有91个属的ICC>0.5,表明它们在一年内相对稳定.
- 确定了三个不同的肠道微生物群子组 (细菌菌,Prevotella 9,Ruminococcaceae).
- 较高的饮食指数与22个属的丰富性相关,特别是那些与较高的水果,蔬菜,全谷物和坚果摄入量相关的属.
结论:
- 39%的肠道属表现出足够的稳定性 (ICC>0.5),用于前性健康研究.
- 饮食模式 (北欧,地中海,植物性) 影响了细菌子组,并与纤维降解细菌的丰富性增加有关.
- 增加水果,蔬菜,全谷物和坚果的摄入量经常与有益的肠道疾病有关.
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