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在斑马鱼中,父母的先入为主的压力会在后代中引起长期的焦虑

Venkata Yeramilli¹, Cristina Sanchez Rizek¹, Jessica Graham¹

¹Dept of Surgery, Washington University School of Medicine, Saint Louis, MO, US.

Physiology & behavior

|February 1, 2024

概括

怀孕前父母的压力会改变后代的大脑发育. 斑马鱼研究表明,母亲或父亲的孕前压力会导致后代的终身焦虑行为.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
行为科学行为科学

背景情况:

早期的生活压力会影响脊椎动物的大脑发育和成人健康.
环境信号在不同发育阶段对大脑发育的确切影响仍然不清楚.
父母先入为主的压力对后代神经发育的影响尚不清楚.

研究的目的:

为了研究父母在受孕前的压力如何影响后代的神经发育和行为.
用斑马鱼模型检查母亲和父亲预孕压力的影响.
评估暴露于父母压力的后代的焦虑相关行为.

主要方法:

利用斑马鱼的慢性不可预测的压力模型.
在三种与焦虑相关的范式中评估后代的行为:新型坦克测试,tighmotaxis和shoaling.
评估从幼虫到成人的行为变化.

主要成果:

在 thigmotaxis 试验中,受压力女性的幼虫表现出类似焦虑的行为.
压力较大的父母的成年后代在新型坦克和冲测试中表现出类似焦虑的行为.
父母的预孕压力导致后代神经发育的持久变化.

结论:

父母的先入为主的压力会导致后代终身的神经发育变化.
无论是压力大的父亲还是母亲,慢性上升的葡萄糖皮质激素信号都会影响后代的神经发育.
斑马鱼是通过母系和父系研究跨代压力影响的宝贵模型.

关键词:

抑郁症抑郁症抑郁症在HPA轴上.神经发育神经发育压力压力压力压力斑马鱼是一种斑马鱼.

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