模拟了两种不同来源的可生物降解微塑料的胃肠道消化和对肠道微生物群的影响
Yujia Peng1, Jianqi Lu1, Lingling Fan1
1Key Laboratory for Waste Plastics Biocatalytic Degradation and Recycling, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China.
概括
生物降解塑料,如PLA和PCL,可能会通过释放更多的微塑料颗粒 (MP) 和破坏肠道微生物群来危害人类健康. 它们在消化道中的降解会导致不良健康影响.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 材料科学 材料科学 材料科学
背景情况:
- 可生物降解塑料被认为是传统塑料的环保替代品.
- 然而,它们对环境和健康的影响,特别是关于微塑料的产生和肠道微生物群的相互作用,需要进行彻底的调查.
研究的目的:
- 在模拟的胃肠道条件下,研究从聚乙烯 (PCL) 和聚乳酸 (PLA) 中生物降解的微塑料颗粒 (MPs) 的命运.
- 评估这些MP及其降解产品对肠道微生物群组成和多样性的影响.
主要方法:
- 实验室模拟的消化和发酵模型被使用.
- 粒子大小分析,扫描电子显微镜 (SEM) 和凝透色谱 (GPC) 被用来描述MPs.
- 使用全长细菌16S rRNA基因安普利康测序检测到肠道微生物群的变化.
主要成果:
- 聚甲拉克 (PCL) MPs在上胃肠道中稳定,而聚乳酸 (PLA) MPs在小肠中降解.
- 在结肠发酵过程中,PCL和PLAMP都降解和寡合.
- MPs及其寡合物显著改变了肠道微生物群的组成,减少了α-多样性,并抑制了关键的益生菌物种,包括Bifidobacterium和Lactobacillus.
结论:
- 可生物降解塑料的可降解性质可以导致人体消化系统内增加微塑料颗粒的产生.
- 可生物降解的MPs通过破坏肠道微生物群构成潜在的健康危害.
- 需要进一步的研究来了解微塑料和肠道微生物群之间的复杂相互作用.
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