在患有扩张性心肌病的患者中,左心室轨道骨折分析的预后值
Wei-Hui Xie1, Bing-Hua Chen1, Dong-Aolei An1
1Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
概括
左心室最大角碎形维度 (FD) 预测了扩张性心肌病 (DCM) 患者的不良结果. 这一措施提供了超越传统临床和成像风险因素的增量预后价值.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 生物物理学的生物物理.
背景情况:
- 在使用心血管磁共振 (CMR) 的扩张性心肌病 (DCM) 中,左心室 (LV) 肌肉心脏轨道复杂性的预后影响尚不清楚.
- 这项研究通过在DCM患者的碎形分析研究了LV心肌椎复杂性的预测能力.
研究的目的:
- 在被诊断为DCM的患者中使用碎形分析来评估LV心肌垂体复杂性的预后价值.
- 为了确定LV最大角FD是否提供增量预后信息.
主要方法:
- 预计将在2017年3月至2021年11月期间招募403名DCM患者接受CMR治疗.
- 量化LV trabeculae复杂度使用碎形维度 (FD) 对CMR内心边界的分析.
- 主要终点包括全因死亡和心力衰竭住院;二级终点是心脏死亡,使用考克斯回归和卡普兰-梅尔生存分析进行分析.
主要成果:
- 经过43个月的中位随访,87名患者达到了主要终点,24名患者达到了次要终点.
- 在多变量调整后,LV最大角FD成为不良结果的显著独立预测因子 (HR=1.179,P<0.001).
- 添加LV最大角FD显著提高了传统临床和成像风险因素的预后值 (C-统计:0.84-0.88,P<0.001).
结论:
- 左心室最大角碎形维度是DCM患者不良临床结果的独立预测指标.
- 当与已确定的临床和成像风险因素相结合时,LV最大角FD提供了显著的增量预后价值.
相关概念视频
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
557
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
557
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
1.2K
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.2K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
805
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
805