精准瘤学在晚期乳腺癌中的当前和未来作用
Heather Jacene1, Eric Dietsche2, Jennifer Specht3
1Imaging/Radiology, Dana-Farber/Brigham Cancer Center, Boston, Massachusetts; hjacene@bwh.harvard.edu.
概括
分子成像显示,通过解决瘤异质性,指导晚期乳腺癌治疗具有前途. 新型放射性药物正在加强其作为临床管理中的生物标志物的作用.
科学领域:
- 在瘤学瘤学.
- 放射性药物 放射性药物 放射性药物
- 分子成像学分子成像学
背景情况:
- 乳腺癌是一种异质性疾病,受生物和基因组特征的影响.
- 瘤异质性在优化晚期乳腺癌治疗方面存在挑战.
- 生物学和基因组特征是乳腺癌治疗决策的关键驱动因素.
研究的目的:
- 突出分子成像在高级乳腺癌管理中的潜力.
- 讨论分子成像作为生物标记物的作用.
- 探索分子成像如何引导治疗决策.
主要方法:
- 关于乳腺癌分子成像的最新证据的审查.
- 考虑新型放射性药物及其批准.
- 在晚期乳腺癌中分析瘤异质性.
主要成果:
- 分子成像越来越多地被认为是其在晚期乳腺癌中的潜力.
- 新型放射性药物正在扩大分子成像的实用性.
- 分子成像可以作为影响管理的生物标志物.
结论:
- 分子成像具有重要的潜力,可以指导晚期乳腺癌的治疗.
- 分子成像的使用在临床实践中越来越受欢迎.
- 放射性药物是促进乳腺癌分子成像应用的关键.
相关概念视频
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Vaccines
367
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
367
Tumor Immunotherapy
526
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526
Cancer Survival Analysis
348
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
348
Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K


