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老年人睡眠时间和认知功能之间的关系:NHANES和英国生物库GWAS数据的分析
Min Yu1,2,3, Yang Jiang1,2,3, Xu Gong1,2,3
1Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China.
Biological research for nursing
|February 1, 2024
概括
短时间和长时间的睡眠时间都可能对老年人的认知功能产生负面影响. 保持健康的睡眠模式对于保持这一群体的认知健康至关重要.
科学领域:
- 老年学是一门学科.
- 睡眠科学 睡眠科学
- 认知神经科学 认知神经科学
背景情况:
- 认知能力下降是老年人群的一个重大问题.
- 睡眠时间是一个可修改的生活方式因素,对大脑健康有潜在的影响.
- 以前的研究表明,睡眠和认知之间存在复杂的关系,但老年人的因果关系需要进一步调查.
研究的目的:
- 用国家健康和营养检查调查 (NHANES) 数据集调查老年人睡眠时间和认知功能之间的关联.
- 使用孟德尔随机化 (MR) 分析与英国生物库数据探索睡眠时间和认知表现之间的潜在因果关系.
主要方法:
- 一项观察性研究分析了来自60岁以上2687名参与者的NHANES数据,用加速度计测量睡眠和使用DSST等测试测量认知功能.
- 多变量回归模型评估了习惯性短 (<7h) 或长 (>9h) 睡眠和认知得分之间的关系.
- 双向门德尔随机化利用来自英国生物库的全基因组关联研究数据 (睡眠N=446,118,认知N=257,841) 来推断因果关系.
主要成果:
- 在观察性研究中,习惯性的长时间睡眠 (>9h) 与较低的数字符号替换测试 (DSST) 分数 (OR=0.01,p=0.003) 有显著的关联.
- 在观察分析中,在习惯性短睡眠 (<7h) 和认知功能之间没有发现显著的关联.
- 门德尔的随机化表明,基因预测较低的一般认知表现与习惯性短睡眠 (OR=0.97,p=5.1e-7) 和长睡眠 (OR=0.97,p=8.87e-16) 有因果关系.
结论:
- 无论是短时间还是长时间的睡眠时间,似乎都与老年人认知能力较差的结果有关.
- 这些发现强调了保持最佳睡眠时间对于老年人的认知健康至关重要.
- 对睡眠健康干预措施的进一步研究可能有助于预防认知衰退.
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