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Updated: Jul 4, 2025

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
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A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells

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多重查揭示了癌症特异性的替代多基化如何在体内塑造瘤生长

Austin M Gabel1,2,3,4, Andrea E Belleville1,2,4,5, James D Thomas1,2

  • 1Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Nature communications
|February 1, 2024
PubMed
概括

替代多氨基化 (APA) 失调在癌症中很常见. 这项研究使用CRISPR-Cas9来识别影响瘤生长的特定APA事件,揭示了癌症进展和患者生存的关键驱动因素.

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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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