从中年到晚年的大脑不对称性以及半球大脑年龄
Max Korbmacher1,2,3, Dennis van der Meer4,5, Dani Beck4,6,7
1Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway. max.korbmacher@hvl.no.
Nature communications
|February 1, 2024
概括
灰色和白质的大脑不对称性随着年龄的增长而增加. 半球大脑年龄预测揭示了性别特异,并提供了对大脑衰老和神经疾病发展的见解.
科学领域:
- 神经成像是一种神经成像.
- 大脑衰老 老化大脑
- 神经系统疾病 神经系统疾病
背景情况:
- 人类大脑表现出结构和功能上的不对称.
- 这些不对称性与衰老,精神和神经疾病的发展有关.
研究的目的:
- 用磁共振成像 (MRI) 度量来评估与年龄相关的大脑不对称性的差异.
- 探索半球大脑年龄 (HBA) 预测作为大脑不对称的标记.
主要方法:
- 利用了来自48040名英国生物库参与者的结构和扩散MRI数据.
- 计算区域灰色和白色物质指标以评估不对称性.
- 使用多模式MRI指标进行半球大脑年龄预测.
主要成果:
- 大多数区域灰色和白色物质指标显示不对称性,随着年龄的增长而增加.
- 半球大脑年龄预测与传统的大脑年龄估计相关.
- 左/右HBA差异在较高的年龄下降,而不是白质不对称.
- 在大脑年龄估计中确定了显著的性别特异性差异.
结论:
- 大脑不对称性在衰老和疾病中起作用.
- HBA提供了一个用于大脑不对称性的补充标记.
- 进一步研究老龄化和疾病中的大脑不对称性是有必要的.
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