胃炎和十二指肠炎的全球负担和风险因素:1990年至2019年的观察趋势研究
Yupei Liu1, Jixiang Zhang1, Yingyun Guo1
1Department of Gastroenterology, Renmin Hospital of Wuhan University, No 99 Zhangzhidong Road, WuhanHubei Province, 430060, China.
Scientific reports
|February 1, 2024
概括
全球胃炎和十二指肠炎 (GD) 病例增加,但年龄标准化率下降. 人口老龄化带来了负担,需要有针对性的预防,特别是低收入地区的老年人.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 全球人口老龄化是一个显著的人口趋势,影响疾病负担.
- 胃炎和十二指肠炎 (GD) 是一个显著的公共卫生问题,随着流行病学模式的演变.
研究的目的:
- 分析1990年至2019年的全球发病率,死亡率和残疾调整寿命年 (DALYs) 的全球趋势.
- 调查GD负担与社会人口指数 (SDI),年龄,性别和特定风险因素等因素之间的关联.
主要方法:
- 使用了全球疾病负担 (GBD) 数据库 (1990-2019).
- 计算了年龄标准化的发病率 (ASIR),年龄标准化的死亡率 (ASDR) 和年龄标准化的DALY (AS-DALY).
- 用于趋势分析的雇员估计年度百分比变化 (EAPC) 和用于风险因素评估的皮尔森相关性.
主要成果:
- 全球GD病例在2019年上升至3100万,自1990年以来增加了1200万.
- 尽管总病例增加,但GD的ASIR,ASDR和AS-DALY显示出下降趋势.
- 在ASIR和SDI之间观察到负相关性,而手部卫生不良和维生素A缺乏与ASIR和ASDR正相关.
结论:
- 总体而言,GD的负担有所增加,主要是由于全球人口老龄化.
- 虽然年龄标准化率正在下降,但绝对病例数量正在上升.
- 未来的GD预防策略应优先考虑老年人群,特别是在SDI较低的地区.
相关概念视频
01:17Gastritis-II: Pathophysiology
327
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
327
01:27Gastritis-I: Introduction and Types
427
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
427
01:23Gastritis III: Clinical Manifestations and Management
252
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
252
01:30Peptic Ulcer Disease I: Introduction
168
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
168
01:30Other Disorders of Digestive System
831
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
831
01:29Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
318
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
318