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Published on: September 16, 2022

循环RNA及其在乳腺癌中的潜在诊断和治疗价值

Di Gao^1,2, Can Cui¹, Yaoxuan Jiao¹

¹Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, China.

Molecular biology reports

|February 1, 2024

概括

循环RNAs (circRNAs) 是乳腺癌发展的关键参与者,影响瘤生长和药物耐药性. 这些分子为早期诊断和针对乳腺癌的新疗法提供了有前途的途径.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

乳腺癌 (BC) 仍然是全球女性癌症相关死亡的主要原因.
瘤复发,转移和化疗耐药性是BC管理的主要挑战.
非编码RNAs,特别是循环RNAs (circRNAs),越来越多地被认为是它们在各种疾病中的作用,包括恶性瘤.

研究的目的:

为提供circRNAs在乳腺癌中的多面性作用的概述.
探索circRNAs在BC细胞增殖,入侵和迁移中的参与.
突出circRNAs作为乳腺癌生物标记物和治疗点的潜力.

主要方法:

关于乳腺癌中circRNAs最近研究的文献综述.
在基因调节中分析circRNA与microRNAs (miRNAs) 的相互作用.
检查乳腺癌病原和治疗耐药性中的circRNA功能.

主要成果:

循环RNAs与乳腺癌的发生和进展有关.
这些分子通过miRNA相互作用调节转录和转录后的基因表达.
循环RNAs影响关键过程,如BC细胞的增殖,入侵和迁移.

结论:

循环RNA在乳腺癌的发展和进展中起着重要作用.
循环RNAs显示出作为BC的诊断和预后生物标志物的潜力.
向circRNAs为未来的乳腺癌疗法提供了一个有希望的策略.

关键词:

生物标志物生物标志物乳腺癌乳腺癌乳腺癌药物耐药性药物耐药性药物耐药性转移转移转移转移核武器的扩散环RNA 环RNA 是一个环RNA.

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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...