调节皮肤mycobiome-bacteriome,并用益生菌丰富的油性悬浮剂治疗斑疹性皮肤炎
Mauro Truglio1, Francesca Sivori1, Ilaria Cavallo1
1Microbiology and Virology, San Gallicano Dermatological Institute, IRCCS, 00144, Rome, Italy.
Scientific reports
|February 1, 2024
概括
这项研究表明,EUTOPLAC是一种益生菌治疗,可以有效地减少斑疹性皮炎 (SD) 症状. 它还能使皮肤重新平衡.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 皮肤微生物组研究研究
背景情况:
- 斑疹性皮肤炎 (SD) 影响全球人口的2-5%.
- 皮肤微生物组失调,特别是涉及像马拉塞西亚和细菌这样的真菌,与SD的发展有关.
- 目前对SD的治疗方法往往缺乏针对性的微生物组调节.
研究的目的:
- 为了评估含有 Lactobacillus crispatus P17631 和 Lacticaseibacillus paracasei I1688 (EUTOPLAC) 的油性悬浮剂在治疗SD的疗效.
- 评估EUTOPLAC对SD症状严重性的影响.
- 为了研究EUTOPLAC对皮肤菌群和细菌群的调节.
主要方法:
- 一周的EUTOPLAC治疗疗程给了25名SD患者.
- 症状严重程度在基线 (T0),治疗后 (T8) 和治疗后三周 (T28) 评估.
- 使用分子技术分析了皮肤菌生体和细菌组合,并对微生物相互作用进行了网络分析.
主要成果:
- 欧托普拉克治疗导致SD症状显著改善.
- 在治疗后观察到,马拉塞西亚属的丰富性显著减少.
- 细菌转移包括斯塔菲洛科克斯的减少和有益的属的增加,如Lactobacillus和Lacticaseibacillus.
结论:
- 欧托普拉克显示出作为治疗斑性皮肤炎的向治疗剂的潜力.
- 该疗法有效调节皮肤菌群-细菌群平衡,有助于缓解症状.
- 根据这些发现,对SD的益生菌干预措施的进一步研究是有必要的.
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