在使用国家免疫计划注册数据的儿童接种肺炎球菌合疫苗后的神经和免疫学不良事件
Ju Hwan Kim1,2, Dongwon Yoon1,2, Hyesung Lee1,2
1School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, South Korea.
International journal of epidemiology
|February 1, 2024
概括
评估了肺炎球菌合疫苗 (PCV) 的安全性. 虽然发烧发作的几率略有增加,但PCV通常是安全的,不应该阻止接种疫苗.
科学领域:
- 免疫接种和疫苗安全性
- 儿科健康结果的结果
- 公共卫生监督 公共卫生监督
背景情况:
- 对肺炎球菌合疫苗 (PCV) 的许可后监测发现了需要调查的安全问题.
- 这项研究解决了与婴儿标准三剂PCV计划相关的潜在过渡性风险.
研究的目的:
- 为了评估肺炎球菌结合疫苗 (PCV) 在三剂婴儿免疫接种系列后的安全性.
- 调查PCV注射与特定不良事件之间的关联.
主要方法:
- 使用韩国免疫和行政索赔数据 (2018-2022) 进行基于人口的队列研究.
- 自主控制的风险间隔分析应用于PCV接受者,以比较风险和控制时期的结果.
- 分析的结果包括过敏反应,喘,脑病,发烧发作,川崎病和血栓塞缩症.
主要成果:
- 分析包括1,114,096名PCV接受者;8,661个经历了结果.
- 肺炎球菌合疫苗 (PCV) 与大多数研究结果的风险增加无关.
- 观察到过渡性发烧发作风险增加 (IRR为1.27,95% CI为1.10-1.47).
结论:
- 一般来说,PCV的使用与严重安全问题的风险增加无关.
- 观察到的发烧性风险的短暂增加是最小的,预后良好.
- 这些发现支持对常规儿童免疫接种PCV安全性的持续信心.
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