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Updated: Jul 4, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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超快速的无标签量化和全面的蛋白质组覆盖,采用狭窄窗口数据独立获取

Ulises H Guzman1, Ana Martinez-Val1, Zilu Ye1,2

  • 1Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.

Nature biotechnology
|February 1, 2024
PubMed
概括

一个新的狭窄窗口数据独立获取 (nDIA) 策略提高了蛋白质组表征的速度和深度. 这种先进的质谱方法实现了更高的蛋白质覆盖率,以实现更快,更全面的蛋白质组分析.

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相关概念视频

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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