慢性肝病与骨疾病和肌肉衰弱的关联
Chisato Saeki1, Mitsuru Saito2, Akihito Tsubota3
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Journal of bone and mineral metabolism
|February 1, 2024
概括
慢性肝病 (CLD) 往往导致骨质疏松 (骨质疏松症) 和肌肉衰竭 (骨质疏松症),经常同时发生骨质疏松症. 这些疾病的早期识别和管理对于改善患者的治疗结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 骨和矿物质的新陈代谢.
背景情况:
- 慢性肝病 (CLD) 破坏营养代谢,激素平衡和肠道健康,导致全身炎症.
- 肝功能受损导致骨改造 (骨质细胞/骨质细胞活动) 和肌肉质量失衡.
- 骨质疏松症和肉症是CLD的常见并发症,显著影响生活质量和生存率.
研究的目的:
- 审查患有CLD的患者骨质疏松症,肉症和骨质疏松症的临床特征和影响.
- 突出共享的风险因素和病理生理机制,这些肌肉骨疾病的基础.
- 强调对CLD骨质沙症的综合管理策略的必要性.
主要方法:
- 本综述综合了关于骨质疏松症,肉症和骨肉症在CLD的背景下现有的文献.
- 它检查了临床数据和病理生理路径,将肝功能障碍与骨和肌肉健康联系起来.
- 该审查考虑了跨CLD各种病因学的研究.
主要成果:
- 骨质疏松症,以骨质损失为特征,是CLD的常见并发症,增加死亡风险.
- 肉症,定义为肌肉质量和功能的逐渐丧失,在CLD中也很常见,并与不良事件相关.
- 骨质疏松症和麻症在CLD患者中经常同时存在 (骨质疏松症),由于类似的潜在机制,加剧了疾病的严重程度.
结论:
- 骨质疏松症和肉症是CLD的重要并发症,并且经常同时发生.
- 共同的病理生理学强调了同时解决骨和肌肉健康的重要性.
- 综合管理方法对于改善患有骨质缩症的CLD患者的预后至关重要.
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