在急性缺血性中风中休息状态功能连接的破坏:右半球和左半球冲击之间的比较
Marilise Katsurayama1, Lucas Scárdua Silva1, Brunno Machado de Campos1
1Laboratory of Neuroimaging, Department of Neurology, University of Campinas, Cidade Universitária, Campinas, SP, 13083-970, Brazil.
Brain topography
|February 1, 2024
概括
左半球中风显著破坏大脑网络,导致功能连接减少,长期恢复较差. 右半球中风显示大脑相反侧的功能连接增加.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 神经学 神经学
背景情况:
- 很少有研究在急性缺血性中风 (AIS) 中研究休息状态功能磁共振成像 (RS-fMRI).
- 损伤横向性对大脑功能连接 (FC) 和结果的影响仍未得到充分研究.
研究的目的:
- 在AIS患者的12个大规模网络中描述大脑功能连接 (FC) 的变化.
- 评估大脑侧面的侮辱 (右半球与左半球) 如何影响这些网络中断.
主要方法:
- 在中风72小时内从38名AIS患者 (17右半球,21左半球) 和44名健康对照中获得RS-fMRI扫描.
- 分析涉及使用UF2C和SPM12软件在12个网络中从70个感兴趣区域生成相关性矩阵.
- 统计分析使用ANCOVA与FDR校正来确定显著的群体差异.
主要成果:
- 左半球 (LH) 的侮辱与六个月后更差的临床结果有关.
- LH中风显示广泛降低了FC,而右半球 (RH) 中风则呈现了相反的增加的FC.
- 在AIS患者组和对照组之间观察到FC模式的显著差异.
结论:
- 轻激素中风诱导大脑网络FC的严重,广泛减少,可能会影响长期恢复.
- RH中风呈现出明显的改变FC模式,表明不同的恢复机制.
- 损伤方面显著影响大脑网络的破坏和AIS后的功能结果.
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