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在青春期暴露于基于草甘的除草剂会加剧雌性小鼠的高脂肪饮食引起的肥胖症
Ana Paula Farina Rosolen1, Rosane Aparecida Ribeiro2,3, Jakeline Liara Teleken1
1Laboratório de Fisiologia Endócrina E Metabolismo (LAFEM), Centro de Ciências Biológicas E da Saúde, Universidade Estadual Do Oeste Do Paraná (UNIOESTE), Cascavel, CEP: 85819-110, Brazil.
Environmental science and pollution research international
|February 1, 2024
概括
在青春期暴露于草甘基除草剂 (GBH) 显著加剧了雌性小鼠的高脂肪饮食引起的肥胖症. 这种农药暴露似乎重编程脂质代谢,当与肥胖性饮食相结合时,增加肥胖风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 草甘基除草剂 (GBH) 是全球普遍存在的农药.
- 之前的研究表明,GBH可能导致各种有机功能障碍.
- 青春期GBH暴露对成年肥胖易感性的影响需要研究.
研究的目的:
- 为了确定青春期暴露于GBH是否会增加成年雄性和雌性小鼠的肥胖易感性,这些小鼠被食高脂肪饮食 (HFD).
- 研究GBH对体重,食物摄入量,脂肪积累和荷尔蒙特征的影响.
主要方法:
- C57Bl/6小鼠 (4-7周大) 接受了水 (CTL) 或50毫克的GBH/kg BW.
- 随后,从8-21周大小的小鼠被食了一个标准或HFD.
- 评估的体重,食物摄入量,身体组成,脂肪细胞形态和血皮质醇水平.
主要成果:
- 青春期的GBH暴露只在雌性小鼠中加剧了HFD诱导的体重增加和过.
- 暴露于GBH和HFD的雌性小鼠表现出脂肪沉积增加 (周周,皮下,棕色脂肪组织) 和瘦肉量减少.
- 两种性别的GBH暴露导致血皮质醇水平升高,女性HFD的增加更为明显.
- 在男性和女性GBH-HFD组中都观察到过度缩的白色脂肪细胞.
结论:
- 青春期的GBH暴露显著恶化HFD诱导的肥胖症,特别是在成年雌性小鼠中.
- 暴露于GBH似乎错误地编程了脂质代谢,在代谢压力下为个人加速肥胖发展做准备.
- 这项研究强调了早期接触农药的潜在长期代谢后果.
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