在控制不良的2型糖尿病中,非阻塞性冠状动脉慢流的预测因素:一个横截面研究
Moataz Ali Hasan Ali Elsanan1, Islam Hussein Hassan Hussein Tahoon1, Ghada Ibrahim Mohamed1
1Department of Cardiology, Faculty of Medicine, Zagazig University, Sharkia Governorate, Zagazig, 44519, Egypt.
BMC cardiovascular disorders
|February 2, 2024
概括
在2型糖尿病 (T2DM) 中,患有非阻塞性冠状动脉疾病 (CAD) 的患者,高血压,吸烟和血红素是冠状动脉缓慢流动 (CSF) 的关键危险因素. 血糖控制不良会增加风险,特别是中性细胞与淋巴细胞比率 (NLR) 升高.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
背景情况:
- 冠状动脉慢流 (CSF) 机制尚未完全理解.
- 脑脊液与炎症,内皮功能障碍和葡萄糖控制不良有关.
- 在非阻塞性冠状动脉疾病 (CAD) 的2型糖尿病 (T2DM) 中确定CSF风险因素至关重要.
研究的目的:
- 为了确定非阻塞性CAD的T2DM患者中CSF的风险因素.
- 探索血糖控制和CSF风险因素之间的关系.
- 为预测该患者群体中CSF提供见解.
主要方法:
- 120名T2DM患者进行冠状动脉血管造影的前性队列研究.
- 根据血糖控制 (充足/差) 和脑脊液存在 (TIMI框架数>27) 进行分类的患者.
- 分析风险因素,包括高血压,吸烟,失脂症,血红素和炎症标志物 (NLR,PLR).
主要成果:
- 高血压 (5.33倍) 和吸烟 (3.2倍) 增加了具有足够血糖控制的患者中CSF风险.
- 血红素 (2.3x) 和PLR (1.053x) 也增加了脑脊髓炎的风险.
- 在血糖控制不佳的情况下,血红素 (2.63x) 和NLR (24.6x) 显著增加了CSF风险;NLR与血糖参数相关.
结论:
- 高血压,吸烟,BMI,血小板计数,血红素,NLR,PLR和CRP与T2DM患者的血糖控制相关.
- 这些因素可以预测T2DM中CSF的可能性.
- 了解这些关联有助于在非阻塞性CAD的糖尿病患者中管理CSF.
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