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了解免疫介导的/过敏对骨科植入物:一个元合成审查

Arnold Chen¹, Andrew P Kurmis^2,3,4

¹School of Medicine, University of Adelaide, Adelaide, SA, 5000, Australia.

Arthroplasty (London, England)

|February 2, 2024

概括

关节置换手术正在上升,对植入物的过敏反应也在上升. 目前的过敏测试是不可靠的,但新的细胞和遗传测试显示出诊断/过敏的前景.

科学领域:

整形外科手术整形外科手术
免疫学免疫学免疫学
材料科学材料科学材料科学

背景情况:

在全球范围内,关节置换手术的数量正在增加.
对植入物,特别是/的过敏反应是一个公认的问题.
对关节置换部件的免疫媒介反应性需要进一步调查.

研究的目的:

审查当前对关节置换中的/过敏的理解.
提出可疑免疫反应的管理算法.
为了解决诊断和管理的有限证据基础.

主要方法:

按照PRISMA指导方针进行系统的文献审查.
对36篇相关文章的分析.
专注于免疫介导的对关节置换部件的反应性.

主要成果:

大多数确定的研究的科学证据很低 (案例系列,专家意见).
有限的同质定量数据阻碍了队列比较.
目前的诊断方法,如病史和皮肤贴片检测,可靠性不佳.

结论:

诊断和管理植入物过敏的证据有限.
患者报告的过敏和皮肤贴片测试对于真正的免疫反应性是不可靠的.
在体外细胞激活和基因测试显示出潜力,但需要进一步验证和可访问性改进.

关键词:

过敏过敏是一种过敏.关节整形术是指关节的整形术.(Chromium) 是一种含的物质.科巴尔特是一种.过敏症是一种过敏症.整形外科的植入物.

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