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在肺结核病例中测量与咳相关的生活质量和咳频率
R D Turner1, S S Birring2, G H Bothamley3
1Department of Respiratory Medicine, Homerton University Hospital, London, UK;, Department of Respiratory Medicine, Gold Coast University Hospital, Southport, QLD, School of Medicine and Dentistry, Griffith University, Gold Coast, QLD, Australia.
概括
莱斯特咳问卷 (LCQ) 是测量肺结核 (PTB) 患者主观咳的有效工具. 然而,患者报告的咳严重程度与客观测量的咳频率没有很强的相关性.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 临床测量 临床测量
背景情况:
- 咳是肺结核 (PTB) 的主要症状,也是疾病传播的关键因素.
- 目前,还没有有效的工具来测量PTB患者咳的主观影响.
- 了解患者报告的咳对于评估疾病负担和传播风险至关重要.
研究的目的:
- 验证莱斯特咳问卷 (LCQ) 用于评估患者报告的PTB咳.
- 调查主观咳 (LCQ分数) 与PTB患者客观咳频率之间的关系.
- 评估LCQ在监测PTB治疗中的有用性.
主要方法:
- 莱斯特咳问卷 (LCQ) 被用在英国一家医院的30名新诊断的PTB患者身上.
- 将LCQ得分与非咳临床变量进行了比较.
- 使用莱斯特咳监测器在24小时内测量了目标咳频率,并与LCQ得分相关联.
主要成果:
- LCQ显示了良好的可接受性,高的内部可靠性 (克朗巴赫的α=0.93),以及与咳严重程度的同时有效性 (ρ=-0.69).
- LCQ显示对治疗的显著反应,在2周后的中位数得分增加 (P = 0.003).
- 在患者报告的咳和客观测量的24小时咳频率之间观察到中等相关性 (ρ = -0.48,P = 0.008).
结论:
- 莱斯特咳问卷 (LCQ) 是一个有效和可靠的工具,用于评估PTB患者的主观咳.
- 可以使用LCQ来监测PTB的治疗反应.
- 在患者主观咳经验和客观咳测量之间存在显著差异,影响诊断和传播评估.
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