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Saroj Chandra Lohani^1,2, Amanda E Ramer-Tait^3,4, Qingsheng Li^1,2

¹School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.

|February 2, 2024

概括

高脂肪饮食 (HFD) 消费改变了肠道微生物群,增加了炎症,在人性化的小鼠模型中显著提高了对HIV-1直肠传播的易感性. 这突出了饮食作为HIV-1感染的潜在风险因素.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
病毒学病毒学
营养科学营养科学

背景情况:

高脂肪饮食 (HFD) 与肠道健康问题,炎症和各种疾病有关.
HFD对HIV-1直肠传播的影响,这是与男性发生性关系 (MSM) 的男性的主要感染途径,尚不清楚.
了解饮食对肠道微生物群和炎症的影响对于评估HIV-1易感性至关重要.

研究的目的:

调查HFD养对肠道微生物群组成和炎症的影响.
确定HFD诱导的变化对HIV-1直肠传播敏感性的影响.
评估饮食诱导的肠道失调和炎症在促进病毒感染中的作用.

主要方法:

使用了一种双人化骨髓,肝脏,胸腺 (dHu-BLT) 鼠标模型.
服用HFD并评估肠道微生物组成和炎症媒介的变化 (IL-12p70,IP-10,ICAM-1,便calprotectin).
暴露于HFD养和对照小鼠的重复低剂量HIV-1直肠挑战,以评估传播易感性.

主要成果:

在dHu-BLT小鼠中,HFD食在3周内改变了肠道微生物组成.
与对照组相比,HFD养的小鼠表现出明显更高的炎症媒介水平.
接受HFD治疗的小鼠对HIV-1直肠感染的敏感性显著增加.

结论:

HFD养会诱导肠道微生物失调和全身炎症.
饮食引起的肠道变化显著增加了对HIV-1直肠传播的易感性.
消费HFD可能是增加HIV-1易感性的风险因素.

关键词:

在HFD中,HFD是指HFD.艾滋病毒-1直肠传播微型企业,微型企业,微型企业.双人化BLT小鼠双人化BLT小鼠肠道微生物失生症是什么炎症标志物炎症标志物

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