[对于局部发达直肠癌的新辅助化学放射治疗的短期结果]
Yuki Sakamoto1, Hidetaka Kurebayashi, Satoko Sakamoto
1Dept. of Surgery 1, University of Fukui.
Gan to kagaku ryoho. Cancer & chemotherapy
|February 2, 2024
概括
新辅助化学辐射疗法 (NACRT) 是对局部晚期直肠癌的安全有效的术前治疗方法. 这项研究发现,NACRT在最小的不良事件下实现了高响应率,显示出出色的局部控制.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
背景情况:
- 新辅助化学辐射疗法 (NACRT) 越来越多地用于局部发达的直肠癌.
- 对NACRT的指示包括临床T3-4和/或cN阳性疾病.
- 在这种患者群体中评估NACRT的疗效和安全性至关重要.
研究的目的:
- 追溯评估NACRT在局部晚期直肠癌患者中的疗效和安全性.
- 为了确定NACRT后的响应率,病理结果和复发模式.
- 评估NACRT的本地控制和安全概况.
主要方法:
- 从2018年11月到2022年7月接受NACRT的11名患者的回顾性分析.
- 患者有局部发达的直肠癌 (cT3-4和/或cN阳性).
- 收集的数据包括人口统计,临床阶段,不良事件,反应率,病理结果和复发.
主要成果:
- 所有11名患者完成了NACRT,没有3级以上的不良事件或治疗中断.
- 总体响应率为72.7%,病理下降率为45.5%,病理完整响应率为9.1%.
- 在所有病例中,手术边缘都是负的,只有18.2%的患者患有远程复发 (肺转移),没有观察到局部复发.
结论:
- NACRT是局部晚期直肠癌的相对安全的术前治疗方法.
- NACRT显示了高的局部控制和有利的病理反应率.
- 进一步的研究可以探索优化NACRT协议以改善患者的治疗结果.
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