[使用基于的化疗对食道癌患者的食道癌患者的功能受损]
Atsushi Takeno1, Motohiro Hirao, Takuya Hamakawa
1Dept. of Surgery, NHO Osaka National Hospital.
Gan to kagaku ryoho. Cancer & chemotherapy
|February 2, 2024
概括
对于不能接受标准化疗的转移性食道癌患者来说,降低5-FU和西斯 (CF) 的剂量至关重要. 这项研究表明,适当的剂量调整可以在功能受损的患者中保持治疗疗效和安全.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 转移性食道癌的第一线化疗通常涉及5-FU和西斯 (CF).
- 对于患有功能减弱 (不适合CF治疗方案) 的患者,治疗策略仍然是一个挑战.
- 免疫检查点抑制剂越来越多地与化疗结合使用.
研究的目的:
- 评价剂量调整后的5-FU和西斯 (CF) 化疗在转移性食道癌患者中具有不同程度的功能时的安全性和有效性.
- 确定患有肌素清除受损的患者的最佳化疗策略.
主要方法:
- 对50名转移性食道癌患者的回顾性分析,这些患者在2018-2022年期间接受了含的化疗.
- 根据基线估计的肌素清除值 (Ccr),患者被分为四组:A组 (>60毫升/分钟),B组 (50-59毫升/分钟),C组 (30-49毫升/分钟) 和D组 (<30毫升/分钟).
- 治疗结果,包括临床响应率和不良事件,在各组之间进行了比较,重点关注西斯丁剂量修改 (CDDP).
主要成果:
- 与A组相比,B,C和D组的老年患者和功能下降 (1级) 患者比例较高.
- 在B,C和D组中,超过一半的患者需要降低西斯普拉丁 (CDDP) 的剂量,根据Ccr进行了适当的调整.
- 临床反应率为65% (A组),42% (B组),60% (C组) 和50% (D组).
- 没有患者因不良事件而停止治疗.
结论:
- 适当减少5-FU和西斯 (CF) 治疗方案的剂量对于治疗转移性食道癌患者和功能受损患者至关重要.
- 剂量调整的CF化疗可以安全地进行,在这个患者群体中保持可接受的反应率.
- 优化CF治疗方案剂量至关重要,特别是因为它仍然是食道癌治疗中免疫检查点抑制剂的关键合作伙伴.
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