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黑人婴儿的微生物组功能和神经发育:维生素B12成为一个关键因素
Kaitlyn Oliphant1, Wilfredo Cruz Ayala1, Rimma Ilyumzhinova2
1Department of Pediatrics, University of Chicago, Chicago, USA.
Gut microbes
|February 2, 2024
概括
肠道微生物群对儿童大脑发育产生影响. 肠道微生物群中的特定细菌和维生素B12的产生显示出在面临健康差异的黑人婴儿中支持神经发育的潜力.
科学领域:
- 微生物组研究的研究.
- 神经发育科学 神经发育科学
- 儿科卫生健康 儿科卫生健康
背景情况:
- 早期的肠道微生物群影响大脑发育.
- 健康方面的种族差异不成比例地影响黑人儿童的神经发育.
- 关于肠道微生物组在黑人儿童神经发育中的作用的研究有限.
研究的目的:
- 调查肠道微生物组组成/功能和黑人婴儿神经发育之间的关联.
- 确定特定的微生物目标,以支持弱势群体的神经发育.
- 为了解决有关黑人儿童肠道微生物组的知识差距.
主要方法:
- 招募了来自城市低收入社区的黑人婴儿子样本.
- 分析了便样本,使用16S rRNA基因测序,枪元基因组学和代谢学.
- 通过测试,母亲报告和观察压力调节来评估神经发育.
主要成果:
- 确定了两种不同的微生物群体类型:一种高在Lachnospiraceae,另一种在Enterobacteriaceae.
- 一个 *Enterobacteriaceae* 主导的微生物组与男婴的认知和语言有负面关联.
- 维生素B12生物合成与所有测量的发育技能 (认知,语言,运动,急诊,努力控制,压力调节) 有积极关联.
- 蓝种是维生素B12生物合成和其他有益功能的关键贡献者.
结论:
- 肠道微生物组的组成和功能与黑人婴儿的神经发育结果有关.
- 维生素B12生物合成和蓝物种显示出作为治疗点的希望.
- 像维生素B12或*Blautia*益生菌这样的干预措施可以支持风险婴儿的神经发育.
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