在小儿血液瘤学患者体外膜氧化支持的结果

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Hong Yul An^1,2, Hyoung Jin Kang^1,2, June Dong Park¹

¹Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Acute and critical care

|February 2, 2024

概括

身体外膜氧化 (ECMO) 为接受化疗或血造干细胞移植 (HSCT) 的儿科癌症患者提供了可行的治疗方法. 存活率各不相同,一些患者存活了败血症,但没有ARDS.

科学领域:

儿科重症监护医药儿科重症监护医药
血液学 - 瘤学
支持心肺血管的支持.

背景情况:

对患有恶性瘤的儿科患者进行血造干细胞移植 (HSCT) 和体外膜氧化 (ECMO) 的结果的综述.
专注于先进生命支持和儿童复杂瘤治疗的交集.

研究的目的:

评估ECMO在接受化疗或HSCT的血液恶性瘤儿科患者的可行性和结果.
在这个脆弱人群中,根据ECMO模式和适应症分析生存率.

主要方法:

对接受化疗或HSCT治疗并接受ECMO的儿科血液瘤患者的回顾性分析.
从首尔国立大学儿童医院收集的数据 (2012年1月 - 2020年12月).
纳入标准:需要ECMO的儿科重症监护室 (PICU) 的儿科患者.

主要成果:

21名儿科患者接受了ECMO;14名 (67%) 接受了HSCT,13名 (62%) 患有恶性瘤.
静脉动脉 (VA) ECMO用于感染性休克,ARDS和其他疾病;静脉动脉 (VV) ECMO主要用于ARDS.
整体存活率到出院为24% (5/21);60%的ECMO在感染性休克中存活下来,但所有接受VA或VVECMO的ARDS患者都死亡.

结论:

对于接受化疗或HSCT的儿童癌症患者来说,ECMO是一种潜在的可行的治疗方法,他们面临呼吸或心力衰竭.
结果高度依赖于ECMO的潜在指示,ARDS的生存率较差.
需要进一步的研究,以优化ECMO策略在这个复杂的患者群体.

关键词:

身体外膜氧化氧化造血干细胞移植造血干细胞移植重症监护病房,儿科这是一种新生瘤新生体.

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