一个新的得分来预测前部循环单次皮质下心脏病发作患者的进展
Jing Lin1, Shiying Ruan2, Weipeng Sun3
1Department of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330000, China.
Annals of clinical and translational neurology
|February 2, 2024
概括
一个新的NTS评分有效预测前部循环单次皮下心脏病发作 (ACSSI) 患者的渐进性心脏病发作 (PI). 这7分的得分,使用NIHSS,甘油三指数和心脏病切片,有助于风险分层,以获得更好的患者结果.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 医疗信息学 医疗信息学
背景情况:
- 渐进性心脏病发作 (PI) 对中风患者的功能预后产生负面影响.
- 前循环单次皮下梗塞 (ACSSI) 是一种常见的中风类型.
- 需要在ACSSI患者中预测PI的预测工具,以改善患者管理.
研究的目的:
- 开发和验证一种风险评分,用于预测ACSSI患者的PI.
- 在ACSSI患者中确定与PI相关的独立因素.
- 根据开发的得分,建立PI的风险分层水平.
主要方法:
- 在2020年1月至2022年10月期间,ACSSI 638名患者的回顾性招生.
- 在训练队列 (n=425) 上使用多变量逻辑回归开发风险得分.
- 使用引导重新抽样和评估歧视和校准 (C-统计,Hosmer-Lemeshow测试) 进行得分的内部验证.
主要成果:
- 渐进性心脏病发作 (PI) 在19.0%的患者中发生.
- 开发了一个7分的NTS得分,包括NIHSS得分,甘油三指数和心脏病切片数.
- 在培训和验证队伍中,NTS评分表现出良好的歧视和校准,风险分层分为低风险,中等风险和高风险组.
结论:
- NTS评分是预测ACSSI患者PI的有效和方便的工具.
- 该NTS得分有助于风险分层,可能指导临床决策和改善患者预后.
- 进一步的前性研究可能进一步验证NTS评分的临床实用性.
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