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Updated: Jul 4, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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HERC5 ISG15结合酶的细胞标和氨酸选择性

Xu Zhao1, Jessica M Perez1, Peter A Faull2

  • 1Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.

iScience
|February 2, 2024
PubMed
概括

这项研究确定了人类ISG15结合酶hHERC5.5在1,100种蛋白质上的2000多个ISGylation位点. 研究人员还发现人类和小鼠ISG15连接酶之间存在明显的基质偏好,这影响了先天免疫研究.

关键词:
生物化学 生物化学免疫学 免疫学 免疫学分子生物学分子生物学文字转录学 (Transcriptomics) 是一个学科.

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