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基于的银纳米复合物80S/Ag作为Aggregatibacter actinomycetemcomitans的抑制剂及其体外生物活性

Jung-Chang Kung^1,2,3,4, Tsung-Ying Yang^5,6,7,8, Chun-Cheng Hung^1,9

¹School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Journal of dental sciences

|February 2, 2024

概括

一种基于的新型材料80S/Ag有效地对抗口腔病原体Aggregatibacter actinomycetemcomitans. 这种材料还促进牙重矿化和中和酸性,为牙周病提供了有前途的治疗方法.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
牙科材料牙科材料

背景情况:

聚聚细菌actinomycetemcomitans是牙周病的流行病原体.
在A. actinomycetemcomitans的抗生素耐药性需要替代治疗策略.
在牙科中,开发用于向抗菌药物的新材料至关重要.

研究的目的:

合成一种基于二氧化的材料,其中包含银纳米粒子 (AgNPs),用于抗菌应用.
评估开发材料对A. actinomycetemcomitans的抗菌疗效.
评估材料的生物活性,重点关注氧酸盐的形成和pH调节.

主要方法:

用于制备80S/Ag粉末 (Si,Ca,P,Ag) 的蒸发诱导自组装方法.
通过吸附-溶解,TEM,SAED和FTIR进行纹理分析.
使用磁盘扩散对A. actinomycetemcomitans进行了抗菌活性测试.
在体外生物活性通过浸泡在模拟体液 (SBF) 中进行评估.

主要成果:

成功合成了具有定义组成的80S/Ag材料.
对A. actinomycetemcomitans.表现出显著和长时间 (168小时) 的抗菌活性.
在SBF中观察到酸酸的形成,表明牙重矿化潜力.
在SBF浸泡后报告了增加的pH值,这表明口腔环境中和.

结论:

80S/Ag对A. actinomycetemcomitans具有强大的抗菌性能.
该材料显示生物活性,包括氧酸盐的形成和pH值的增加.
80S/Ag显示出治疗牙周病治疗中治疗应用的巨大潜力.

关键词:

聚合菌是Actinomycetemcomitans的组合体之一.牙周病是指牙周病的发生.基于的银纳米复合材料.银银银银银银银

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