化学致癌物诱导的实验性口腔致癌的科学测量研究,重点是化学预防剂
Ziyuan Zhou1, Xinyi Han2,3, Shukun Shen2,4
1Department of Stomatology, Yixing People's Hospital, Jiangsu, China.
Journal of dental sciences
|February 2, 2024
概括
这项研究分析了4-Nitroquinoline 1-oxide (4NQO) 和7,12-dimethylbenz (a) (DMBA) 诱导的口腔致癌模型中的研究趋势. 它确定了关键的研究主题和潜在的口腔癌化学预防剂.
科学领域:
- 生物医学研究生物医学研究
- 在瘤学瘤学.
- 致癌的发生是致癌的产生.
背景情况:
- 4-Nitroquinoline 1-oxide (4NQO) 和7,12-dimethylbenz(a) anthracene (DMBA) 是经典的化学致癌物,用于口腔致癌的动物模型.
- 这些模型对于了解口腔癌的发展和测试潜在治疗方法至关重要.
研究的目的:
- 分析由4NQO和DMBA诱导的实验性口腔致癌的研究趋势和特征.
- 在这些模型中识别共同的关键词,研究主题和潜在的化学预防剂.
主要方法:
- 在Scopus数据库上对自1962年以来发表的论文进行了全面的文献搜索.
- 数据检索于2023年5月12日进行,重点研究涉及4NQO和DMBA诱导的口腔致癌.
主要成果:
- 分析显示,关于4NQO的506篇论文和关于DMBA的349篇论文,引用数量很高.
- 对于每个模型,确定了不同的关键词:4NQO (老鼠,舌头瘤,饮用水,瘤微环境,COX-2) 和DMBA (仓鼠,脸囊,脂质过氧化,谷,抗氧化剂,局部药物管理).
- 总共有105种潜在的化学预防剂被确定为4NQO模型和65种DMBA模型,其中15种药物 (例如,COX-2抑制剂,黄素,大) 在两者中都被研究.
结论:
- 这项研究提供了第一个科学测量分析4NQO和DMBA诱导的口腔癌发生.
- 已识别的化学预防剂和研究趋势为指导未来口腔癌化学预防研究提供了有价值的资料.
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