乳制品消费和肝癌风险:观察性研究的元分析
Jiaying Dai1, Tong Yin2, Liying Cao1
1Department of Hepatobiliary Surgery, KaiLuan General Hospital, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China.
Oncology letters
|February 2, 2024
概括
高量的牛奶消费可能会增加原发性肝癌 (PLC) 的风险,而酸奶的摄入似乎会降低风险. 这一元分析阐明了乳制品和PLC开发之间的复杂关系.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 营养科学 营养科学
背景情况:
- 乳制品消费与原发性肝癌 (PLC) 风险之间的关联尚未得到充分证实.
- 现有研究提出了关于乳制品摄入量和肝癌发病率的相互矛盾的发现.
研究的目的:
- 进行全面的元分析,研究乳制品消费与患初级肝癌的风险之间的联系.
- 综合来自多项研究的证据,以更好地理解这种关系.
主要方法:
- 在PubMed,Cochrane图书馆和Embase数据库中进行了系统的文献搜索,直到2022年12月.
- 包括10个队列和8个病例控制研究,包括6,562,714名参与者和7,970个PLC病例.
- 计算的相对风险 (RRs) 使用95%的置信区间 (CI) 来评估关联.
主要成果:
- 较高的牛奶消费与增加的PLC风险有积极的关联 (RR, 1.38;95% CI, 1.07-1.77).
- 酸奶消费显示出负相关性,这表明PLC风险降低 (RR,0.49;95% CI,0.27-0.91).
- 没有发现乳制品,奶酪或乳酪总消费与PLC风险有显著的关联.
结论:
- 研究结果表明,高牛奶摄入量可能会增加PLC风险,而酸奶消费可能会有保护作用.
- 需要进一步的研究来阐明这些差异性关联背后的机制.
- 关于乳制品摄入量和预防肝癌的饮食建议需要细致的考虑.
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