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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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精准医学的前景在硬化皮质硬化症中的精准医学.

Kazuhiro Komura1,2, Koichi Yanaba3, Jean-David Bouaziz4

  • 1Department of Dermatology, Kanazawa Red Cross Hospital, Japanese Red Cross Society, Kanazawa, Japan.

Frontiers in immunology
|February 2, 2024
PubMed
概括

系统性硬化症 (SSc) 研究面临的挑战是由于疾病的稀有性和异质性. 个性化医疗,以体外药物反应测试为指导,对患者的纤维细胞进行测试,为SSc.提供了优化治疗策略的途径.

关键词:
生物标志物 生物标志物纤维化 纤维化精准医学是一门精准医学.系统性硬化症 系统性硬化症治疗疗法治疗疗法治疗疗法

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科学领域:

  • 类风湿病学 类风湿病学
  • 免疫学 免疫学 免疫学
  • 遗传学 是一个遗传学.

背景情况:

  • 系统性硬化症 (SSc) 是一种罕见的,异质的自身免疫性疾病.
  • 鉴定环境和遗传风险因素是具有挑战性的,因为患者人群很小.
  • 疾病的复杂性需要个性化或精准医学方法.

研究的目的:

  • 为改善SSc.治疗策略奠定基础.
  • 提高针对性治疗的临床试验设计.
  • 探索体外药物反应测试以进行个性化治疗选择.

主要方法:

  • 基于受影响区域和疾病标志物 (例如,自身抗体) 的SSc的分类.
  • 临床前体外药物反应测试使用患者衍生纤维细胞.
  • 在培养中分析纤维细胞表型.

主要成果:

  • 结核病皮肤纤维细胞在体外表现出一种持续的高生产性表型.
  • 在体外药物反应测试可以识别精确的疾病标志物.
  • 这种方法有助于为个别患者进行治疗选择.

结论:

  • 个性化医疗对于管理SSc异质性至关重要.
  • 试验室药物反应测定提供了指导SSc治疗的精确方法.
  • 基于疾病标志物的累积方法优化了患者的护理和生活质量.