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淋巴缺血是COVID-19患者死亡率的预测者吗?

Jehat Kılıc¹, Berat Ebik², Ferhat Bacaksız²

¹SBÜ Diyarbakır Gazi Yaşargil EAH, Internal Medicine Department, Diyarbakır, Turkey.

Acta clinica Croatica

|February 2, 2024

概括

淋巴细胞减少,即淋巴细胞数量低,与严重的COVID-19结果和死亡率有很强的相关性. 这种易于测量的因素可以帮助管理COVID-19患者并预测疾病严重程度.

科学领域:

传染性疾病传染性疾病
血液学血液学血液学
关键护理医学关键护理医学

背景情况:

淋巴缺血是病毒感染的常见发现,包括COVID-19.
在COVID-19患者中淋巴缺血的预后意义需要进一步阐明.

研究的目的:

为了评估淋巴缺血和需要重症监护室 (ICU) 入院或COVID-19患者的死亡率之间的关联.
为了确定淋巴缺血是否可以作为严重COVID-19的预后因素.

主要方法:

分析了1670名COVID-19患者的队列.
患者根据感染时的淋巴缺血严重程度对患者进行分类.
严重程度根据症状和ICU要求分为轻度或重度.

主要成果:

严重的COVID-19发生在34.4%的患者中,死亡率为12.7%.
淋巴细胞数量低 (<500细胞/mcL) 的患者患重病的发病率显著更高 (64.7%对5.2%).
淋巴缺血与严重疾病的几率增加 (OR 2.4) 和严重感染 (8.9倍) 和死亡率 (12.4倍) 的风险显著增加有关. ROC分析表明淋巴细胞计数<615细胞/mcL,对严重疾病有96.4%的敏感性.

结论:

淋巴缺血是COVID-19的显著预后因素,与疾病严重程度和死亡率有很强的相关性.
测量淋巴细胞计数是一种简单,具有成本效益的方法来预测COVID-19的结果.
淋巴缺血的评估可以帮助COVID-19患者的临床管理.

关键词:

在 COVID-19 疫情中,淋巴细胞减少症 (Lymphopenia) 是一种死亡率死亡率死亡率

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