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对血液形成细胞移植候选人的方法与呼吸道病毒检测

Sara R Kim^1,2, Alpana Waghmare^1,2,3, Diego R Hijano^4,5

¹Division of Pediatric Infectious Diseases, Seattle Children's Hospital, Seattle, WA, United States.

Frontiers in pediatrics

|February 2, 2024

概括

在输血细胞移植 (HCT) 之前管理呼吸道病毒是复杂的. 本综述详细介绍了移植前呼吸道病毒感染的指导方针和文献,为临床医生提供了实际指导.

科学领域:

传染性疾病传染性疾病
血液学血液学血液学
移植医学移植医学

背景情况:

在输血细胞移植 (HCT) 之前对呼吸道病毒的管理存在挑战.
指南建议对某些病毒 (例如,腺病毒,RSV) 进行移植延迟,但对其他病毒 (例如,SARS-CoV-2) 存在模糊性.

研究的目的:

审查目前关于移植前呼吸道病毒感染 (RVI) 的文献和临床指南.
为在HCT候选人中管理RVI的临床医生提供实际指导.
讨论RVI的抗病毒疗法和预防策略.

主要方法:

关于移植前RVI的文献综述.
对临床实践指南的分析.
讨论三个代表性的临床情景.

主要成果:

对于像腺病毒和RSV这样的常见RV存在既定的指导方针,经常建议移植延迟.
在管理较少见的RV,如季节性冠状病毒和SARS-CoV-2等方面存在显著的模两可.
抗病毒疗法和预防策略是可变的,取决于特定的病毒和宿主因素.

结论:

移植前的RVI管理需要仔细考虑宿主因素,移植参数和特定的病毒.
需要进一步的研究和更明确的指导方针来管理HCT候选者的较少常见的RVI.
基于病例的方法可以帮助临床医生在复杂的移植前RVI场景中进行导航.

关键词:

癌症癌症癌症癌症癌症孩子们的孩子们的孩子们的孩子们.血造细胞移植是血造细胞的移植.免疫性受损的人.呼吸道病毒的病毒

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