在口腔状细胞癌中过度表达duebiquitinase (usp36)
Preethi Murali1, B Kavitha1, Malathi Narasimhan2
1Department of Oral and Maxillofacial Pathology and Oral Microbiology, Meenakshi Ammal Dental College and Hospital, MAHER, Chennai, Tamil Nadu, India.
Journal of oral and maxillofacial pathology : JOMFP
|February 2, 2024
概括
这项研究发现,口腔状细胞癌 (OSCC) 患者的USP36基因表达增加. USP36在OSCC的所有分化阶段都被上调,这表明它在口腔癌发育中的作用.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 口腔癌,特别是口腔状细胞癌 (OSCC),是印度的主要公共卫生问题.
- 随处化/脱随处化的调节失调,这是一个关键的翻译后修饰,与癌症的发展有关.
- 有限的研究存在于OSCC中无处不在的作用,突出了知识差距.
研究的目的:
- 在口腔状细胞癌 (OSCC) 组织中研究泛素特异性蛋白酶36 (USP36) 的基因表达.
- 确定USP36表达水平是否与OSCC患者的瘤分化相关.
主要方法:
- 使用定量实时PCR分析USP36基因表达.
- 采用了来自15名OSCC患者的组织样本,这些患者处于不同分化阶段,以及年龄/性别匹配的对照.
- 患者根据瘤分化模式进行了分层.
主要成果:
- 与对照组相比,在OSCC患者中观察到USP36基因表达的显著增加.
- 在所有分化级别中,USP36 mRNA水平显著升高:在分化良好时增加231.8 ± 137.94倍,在中度分化时增加38.18 ± 3.77倍,在差分化OSCC时增加25.49 ± 7.30倍.
结论:
- 这项研究首次证实了口腔状细胞癌 (OSCC) 组织中USP36基因表达升高的证据.
- 这些发现表明,USP36可能在OSCC的发病过程中发挥作用.
- 进一步研究USP36在口腔癌中的功能是有必要的.
关键词:
杜比奎廷酶的使用方法RT PCR 在线播放36 usp 36 usp 36 usp 36 usp 36 usp 36 usp 36 usp 36 usp 36 usp 36 usp 36 usp 36 usp 36 usp 36 usp 36更多相关视频
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