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在口腔状细胞癌中USP22和Ki-67表达的评估:一种免疫组织化学研究

Chelikani Chaitra Apoorva¹, Anuradha Ananthaneni¹, A Jagadeesh Kumar¹

¹Department of Oral Pathology, St Joseph Dental College and Hospital, Duggirala, Eluru, Andhra Pradesh, India.

Journal of oral and maxillofacial pathology : JOMFP

|February 2, 2024

概括

该研究发现,口腔状细胞癌 (OSCC) 与正常组织之间USP22和Ki-67表达的显著差异. 虽然这些标记物显示出早期OSCC诊断的潜力,但它们的预后价值需要在更大的队列中进一步调查.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

USP22是瘤生长的关键调节剂,促进瘤增殖和抑制瘤抑制剂.
USP22的过度表达与各种癌症中的Ki-67表达相关,包括口腔状细胞癌 (OSCC).

研究的目的:

评估OSCC组织中USP22和Ki-67的表达水平.
评估USP22和OSCC中的Ki-67表达之间的相关性.

主要方法:

免疫组织化学被用来检测USP22和Ki-67蛋白质的表达.
该研究分析了50个OSCC组织样本和15个正常口腔粘膜样本.

主要成果:

与正常组织相比,USP22和Ki-67在OSCC中的表达显著更高 (P < 0.0001).
在OSCC组织中USP22和Ki-67表达之间观察到微弱的正相关性 (R = 0.19和R = 0.51).

结论:

在OSCC中,USP22和Ki-67的表达显著改变,这表明它们有可能作为诊断生物标志物.
需要进一步研究更大的样本大小,以验证它们在OSCC中的预后意义.

关键词:

基-67 (基尔-67) 是一种气体.OSCC (口腔状细胞癌) 是一种癌症.USP22 (乌比奎丁特异性化酶22) 是一种

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Immunocytochemistry and Immunohistochemistry

Immunocytochemistry and Immunohistochemistry

Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
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