阿尔茨海默病的灰色和白色物质基于voxel的形态测量,有或没有显著的脑血管病理
Chandan Saha1, Chase R Figley1,2, Zeinab Dastgheib1
1Biomedical Engineering Program, University of Manitoba, Winnipeg, MB, Canada.
Neuroscience insights
|February 2, 2024
概括
区分阿尔茨海默病 (AD) 和混合痴呆症 (AD-CVD) 是很困难的. 这项研究使用MRI扫描发现了AD和AD-CVD患者之间灰质和白质大脑体积的微妙差异.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 痴呆症研究 痴呆症研究
背景情况:
- 阿尔茨海默氏症 (AD) 是最常见的痴呆类型,通常与脑血管疾病 (CVD) 一起发生,导致混合痴呆 (AD-CVD).
- 区分AD和AD-CVD,特别是在早期阶段,是一个重大的诊断挑战.
研究的目的:
- 为了比较AD,AD-CVD和健康对照个体之间的灰质 (GM) 和白质 (WM) 脑体积.
- 调查潜在的基于MRI的结构性AD和AD-CVD之间的歧视性特征.
主要方法:
- 用MRI扫描进行基于voxel的形态测量 (VBM) 分析.
- 在83名阿尔茨海默氏症患者,37名阿尔茨海默氏症-心血管疾病患者和85名健康对照人群中比较了GM和WM体积 (来自ADNI,根据年龄和性别匹配).
主要成果:
- 这两个痴呆症组的GM和WM量明显低于对照组 (P<0.05,FWE校正).
- 与AD-CVD相比,AD患者倾向于在左门/右海马中较低的GM和右丘脑中的WM.
- 与AD患者相比,AD-CVD患者在小脑叶区和右脑干区域的GM和WM体积相应较低.
结论:
- 结构性MRI分析显示,与对照组相比,AD和AD-CVD中广泛的GM和WM体积减少.
- 初步发现表明,在AD和AD-CVD之间可能存在微妙的区域体积差异,尽管歧视仍然具有挑战性.
- 需要对更大的样本进行进一步的调查,以确认这些歧视性特征.
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