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持续脏置换疗法和临界疾病肥胖成年人的死亡率
Bradley J Peters1, Erin F Barreto1,2, Kristin C Mara3
1Department of Pharmacy, Mayo Clinic, Rochester, MN.
Critical care explorations
|February 2, 2024
概括
接受连续脏替代疗法 (CRRT) 的重症成人肥胖患者的90天死亡率较低. 建议在肥胖患者中使用CRRT剂量时使用理想体重 (IBW),以确保安全性和有效性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 关键护理医学 关键护理医学
- 肥胖医学 肥胖医学
背景情况:
- 对于接受连续脏替代疗法 (CRRT) 的患有严重疾病的肥胖成年人的结局尚不清楚.
- 这种人群中CRRT剂量对患者结局的影响仍然不确定.
研究的目的:
- 调查肥胖是否为患有急性损伤 (AKI) 需要CRRT的重症患者提供生存优势.
- 为了确定CRRT的处方剂量是否预测该患者群的死亡率.
主要方法:
- 在一个学术医疗中心进行的回顾性观察队列研究.
- 肥胖 (BMI ≥30 kg/m2) 和非肥胖 (BMI <30 kg/m2) 之间30天和90天死亡率的比较,在CRRT上患有AKI的危急病患者成年人.
- 使用多变量回归来评估CRRT剂量,根据实际体重 (ABW),调整体重 (AdjBW) 或理想体重 (IBW) 进行索引,作为死亡率的预测指标.
主要成果:
- 包括1033名患者;中位数BMI为26公斤/平方米 (非肥胖) 和36公斤/平方米 (肥胖).
- 30天死亡率相似 (54%对48%,p=0.06),但在肥胖患者中,90天死亡率较低 (62%对55%,p=0.02).
- 当指数为ABW或AdjBW (HR 1.2-1.16) 时,CRRT剂量预测了增加的死亡率,但不是IBW (HR 1.04).
结论:
- 与非肥胖同行相比,接受CRRT的患有AKI的严重肥胖成人短期死亡率较低.
- 理想体重 (IBW) 索引似乎更适合优化肥胖患者的CRRT剂量,可能提高安全性和有效性.
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