在败血症研究中的残留调查的前性队列协议
Christopher W Seymour1,2, Kelly Lynn Urbanek1,2, Anna Nakayama1,2
1Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Critical care explorations
|February 2, 2024
概括
这项研究研究使用残留生物标本进行败血症研究,发现它们对了解宿主和病原体机制有价值. 这种方法为推进败血症诊断和治疗提供了具有成本效益的替代方案.
科学领域:
- 败血症病理生理学病理生理学
- 生物存储科学科学库
- 机械学研究 机械学研究
背景情况:
- 败血症每年导致超过1100万人的死亡,需要更深入地了解宿主和病原体的作用.
- 当前的研究往往需要昂贵的生物存储库,限制机械学研究.
- 遗留生物样本为败血症研究提供了潜在的替代方案,但它们的生存能力和价值尚未得到证实.
研究的目的:
- 为了确定机械性败血症研究的残留生物标本的科学价值.
- 评估使用残留生物样本在败血症中的多原子分析的可行性.
- 将残留生物样本的数据质量与标准研究级生物样本进行比较.
主要方法:
- 对225名社区获得性败血症的成年患者进行前性队列研究 (败血症-3标准).
- 收集和分析残留生物标本与配对的研究级生物标本 (来自各种管中的血) 一起.
- 评估多原子读数 (蛋白质,小分子,脂质,病原体测序) 的精度,准确性,完整性和可比性.
主要成果:
- 该研究正在进行中,招聘将于2022年10月开始.
- 主要结果预计将在2024年出现.
- 将分析数据,以评估残留生物标本的科学实用性.
结论:
- 在败血症研究中使用残留生物标本正在严格评估中.
- 预计这些发现将为未来的机理学研究中利用这些宝贵资源提供信息.
- 结果将公开传播,以推进败血症研究和临床实践.
更多相关视频
10:38Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
Published on: January 16, 2019
20.2K
06:55Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
14.5K
相关概念视频
Observational Studies
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One example of...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One example of...
Study Designs in Epidemiology
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
