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严重的肝病与白内障的关联使用英国生物银行数据:一个前性队列研究

Chao Chen^1,2,3,4, Ling Wei^1,2,3,4, Wenwen He^1,2,3,4

¹Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.

EClinicalMedicine

|February 2, 2024

概括

严重的肝病,如非酒精性脂肪性肝病 (NAFLD) 和酒精性肝病 (ALD),增加白内障的风险. 这凸显了眼睛护理对于肝脏患者的重要性.

科学领域:

眼科医生眼科眼科
肝病学肝病学是一种肝病学.
公共卫生公共卫生

背景情况:

肝脏疾病与多系统性问题有关,但与白内障等眼睛疾病的联系尚未得到充分研究.
白内障是全球失明的主要原因之一.

研究的目的:

调查严重肝病与患白内障的风险之间的关联.
检查特定的肝脏疾病,包括NAFLD,ALD,病毒性肝炎和肝纤维化/肝硬化.

主要方法:

一项针对英国生物库 (2006-2010) 的326,558名参与者进行的前性研究,没有基线白内障.
严重的肝病是根据住院情况定义的,并分析为二进制和三进制的时间变量.
考克斯比例危险模型用于估计危险比率 (HR) 和95%置信区间 (CI).

主要成果:

在13.3年的时间里,37,064人患上白内障.
严重的NAFLD (HR 1.47),ALD (HR 1.57) 和肝纤维化/肝硬化 (HR 1.58) 与白内障风险增加有关.
最近确诊的病毒性肝炎 (HR 1.55) 也显示出相关性,而长期的病毒性肝炎则没有.

结论:

严重的NAFLD,ALD,肝纤维化/肝硬化和最近的病毒性肝炎是白内障的独立风险因素.
肝眼连接强调了肝病患者眼科监测的必要性.
早期的白内障查和诊断对于患有肝脏疾病的人来说至关重要.

关键词:

酒精性肝病是一种肝病.白内障是什么?白内障是什么?白内障是什么?肝硬化是肝硬化的一种.肝脏纤维化肝脏纤维化非酒精性脂肪性肝病是非酒精性脂肪性肝病.病毒性肝炎的病毒性肝炎.

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