在患有COVID-19疾病的患者中,外周血细胞的形态异常
Anna Karapetyan1, Lyudmila Niazyan2, Ruzanna Shushanyan1
1Department of Human and Animal Physiology, Yerevan State University, 1 Alex Manoogian, RA, Yerevan, 0025, Armenia.
Heliyon
|February 2, 2024
概括
COVID-19感染会改变血液细胞形态和数量,影响淋巴细胞,红细胞和白细胞. 对外围血液涂抹的血液学检查可以揭示这些变化,有助于疾病的识别和严重程度的评估.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- COVID-19患者的血液学变化对公共健康至关重要.
- 周围血液涂抹分析提供了对疾病严重程度和识别的见解.
研究的目的:
- 为了评估COVID-19患者外周血液细胞的形态和定量变化.
- 为了确定与冠状病毒疾病相关的特定血液学异常.
主要方法:
- 对48名COVID-19患者的回顾性分析.
- 血液涂抹的血液学检查,包括分白细胞计数.
- 检测染色体损伤的微核试验和红细胞异常的评估.
- 全血细胞计 (CBC) 用于评估周围血液细胞的变化.
主要成果:
- 观察到中性友好症,乙性友好症,轻度单细胞症,血红素水平降低,ESR升高和白细胞不成熟.
- 在感染患者中观察到轻度的血小板缺血.
- 微核检测揭示了具有微核和红细胞核异常的不成熟淋巴细胞.
结论:
- 完整血细胞计数和周围血液涂抹可以表明SARS-CoV-2对造血和免疫系统的影响.
- 红细胞和白细胞的形态变化与COVID-19疾病的严重程度相关.
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