生物信息学揭示了糖尿病脏病和牙周炎在衰老的背景下之间的病理生理关系
Peng Yan1, Ben Ke1, Xiangdong Fang1
1Department of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Heliyon
|February 2, 2024
概括
糖尿病脏病和牙周炎有共同的与衰老相关的基因和途径,尽管缺乏直接的因果关系. 这项研究确定了潜在的生物标志物,以了解它们在老龄化个体中的共享病原性.
科学领域:
- 生物医学科学 生物医学科学
- 遗传学 是一个遗传学.
- 免疫学 免疫学 免疫学
背景情况:
- 糖尿病病 (DN) 和牙周炎 (PD) 是糖尿病的常见并发症,两者都与加速衰老有关.
- 怀疑糖尿病和牙周炎之间的双向关系,需要对共享机制进行调查.
研究的目的:
- 使用孟德尔随机化 (MR) 探索DN和PD之间的因果关系.
- 使用生物信息学方法识别DN和PD之间的共享交叉基因,与衰老相关的基因和生物途径.
主要方法:
- 进行了门德尔的随机化分析来评估因果关系.
- 生物信息学方法,包括基因查,相关性分析和机器学习算法 (SVM-RFE,MCC),被用来识别关键的交叉交谈衰老基因.
- 进行基因丰富和免疫透分析,以探索共同的途径和细胞作用.
主要成果:
- 核磁共振分析没有发现DN和PD之间因果关系的证据.
- 在DN和PD之间发现了83个重叠的基因. 使用机器学习识别了五个关键的交叉衰老基因 (CSF1R,CXCL6,VCAM1,JUN,IL1B).
- AGE-RAGE信号,补充系统和炎症途径都与这两种疾病的共同特征有关. 观察到不同的免疫细胞表达,特别是树突细胞和T细胞.
结论:
- 虽然没有存在因果关系,但CSF1R,CXCL6,VCAM1,JUN和IL1B代表潜在的交叉衰老基因,连接DN和PD.
- 鉴定到的共同途径和生物标志物为人们提供了关于DN和PD在衰老背景下的共同病原学的见解.
相关概念视频
01:20Pathophysiology of Diabetes
940
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
940
01:19Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
01:15Teeth
424
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
424
01:15Diabetes: Symptoms, Diagnosis, and Complications
544
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
544