束控制系统和输出微调,以在临床线性加速器上安全精确地提供FLASH放射治疗
Elise Konradsson1, Pontus Wahlqvist2, Andreas Thoft2
1Medical Radiation Physics, Department of Clinical Sciences, Lund University, Lund, Sweden.
Frontiers in oncology
|February 2, 2024
概括
这项研究升级了用于超高剂量率 (UHDR) 电子传递的临床线性加速器,实现了稳定而精确的FLASH放射治疗. 新系统提高了未来临床试验的可靠性.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 加速器物理学的物理学
背景情况:
- 临床线性加速器正在适应超高剂量率 (UHDR) 电子传递,以实现FLASH放射治疗.
- 提高UHDR输送的可靠性和精度对于推进临床FLASH放射治疗试验至关重要.
研究的目的:
- 引入和评估一个升级的光束控制系统和光束调节过程,以确保安全和精确的UHDR电子传输.
- 为了提高未来临床FLASH放射治疗的UHDR电子输送的可靠性.
主要方法:
- 开发了一种升级的光束控制系统,基于监控单元,脉冲计数或交付时间的中断功能.
- 建立了一个光束调整过程以最大限度地提高输出,并探索了一种新的方法,将触发脉冲与脉冲形成网络 (PFN) 充电周期同步.
- 评估了超高频传输的稳定性,可重复性和可重复性,以及控制系统的独立中断能力.
主要成果:
- 改进的光束调整实现了超过160 Gy/s的平均剂量率 (或没有外部监控室的200 Gy/s).
- 交付证明了良好的可重复性 (2.2% SD) 和可重复性 (2.6% SD),估计每脉冲剂量 (DPP) 的变化产生1.7% SD.
- 在50次测量中,PFN同步导致交付和预设监视器单元之间的绝对百分比误差很低 (0.8 ± 0.6%).
结论:
- 一个升级的光束控制系统和调过程使得安全,稳定和精确的UHDR电子传送在数百Gy/s.
- 该系统能够基于监控单元中断光束并利用PFN同步,这对于可靠的临床FLASH放射治疗试验来说是一个重大进步.
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