溶性ST2作为急性心力衰竭患者炎症的可能生物标志物
Jiacheng Lai1,2, Chongjian Huang1,3, Bin Li1
1Department of Emergency Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei.
Journal of cardiovascular medicine (Hagerstown, Md.)
|February 2, 2024
概括
在急性心力衰竭 (AHF) 患者中,瘤发生性-2 (sST2) 水平的血清可溶性抑制与炎症生物标志物相关. 这些发现表明sST2
科学领域:
- 心脏病学 心脏病学
- 生物标志物研究 生物标志物研究
- 炎症研究 炎症研究
背景情况:
- 急性心力衰竭 (AHF) 是一种复杂的临床综合征.
- 确定可靠的AHF生物标志物对于患者管理至关重要.
- 瘤发生性-2 (sST2) 的可溶性抑制是心血管疾病中的潜在生物标志物.
研究的目的:
- 研究血清sST2水平与AHF患者的各种炎症生物标志物之间的关系.
- 探索炎症在AHF中sST2作用机制中的潜在作用.
主要方法:
- 纳入了111名AHF患者 (NYHAII-IV类).
- 周围血液是在入院后24小时内收集的.
- 测量了NT-ProBNP,sST2,HS-cTnI,细胞因子 (IL-18),C反应蛋白 (CRP) 和其他常规测试的水平.
主要成果:
- 血清sST2与NT-ProBNP,NEU%,NLR,CRP和IL-18 (P<0.001) 有显著的相关性.
- sST2与Hs-cTnI,NUE,LYM和IL-2RA (P <0.05) 也发生相关性.
- 多重回归分析确定了CRP,IL-18,NEU%,NLR和NT-ProBNP作为sST2水平的重要预测因素.
结论:
- 周围炎症标志物 (CRP,IL-18,NEU%,NLR) 与AHF患者的sST2水平密切相关.
- 在AHF中sST2的机制可能涉及炎症反应.
- sST2水平与住院时间有线关联.
更多相关视频
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
92
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
92
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
158
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
158