早期生命并发症和精神分裂症多基因风险评分之间的相互作用与健康参与者的情绪处理期间的大脑活动有关
Veronica Debora Toro1,2, Linda A Antonucci1, Tiziana Quarto2
1Psychiatric Neuroscience Group, Department of Translational Biomedicine and Neuroscience, University of Bari "Aldo Moro", Bari, Italy.
Psychological medicine
|February 2, 2024
概括
精神分裂症风险涉及遗传倾向和早期生命并发症之间的相互作用,影响腹侧前额叶皮质中的大脑活动. 这个大脑区域的大脑区域.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 精神分裂症 (SCZ) 风险与多基因风险和早期生命并发症 (ELC) 有关.
- 以前的研究表明,ELCs和SCZ多基因风险相互作用,但这种相互作用对神经生物学表型的影响仍然未被探索.
- 在SCZ中观察到与情绪相关的异常大脑活动,但其与遗传风险的联系尚不清楚,可能受到非遗传因素的影响.
研究的目的:
- 调查SCZ相关的多基因风险和ELCs与情绪相关的大脑活动之间的相互作用.
- 确定ELC是否会改变SCZ多基因风险与在情绪处理过程中大脑功能之间的关系.
主要方法:
- 功能磁共振成像 (fMRI) 用于评估282名健康参与者 (HP) 在发现和复制样本中的情绪处理期间的大脑活动.
- 参与者进行了ELC的评估,并进行了全基因组基因型定型,以计算SCZ多基因风险评分 (PRS).
- 75名SCZ患者的脑活动模式与HP进行了比较,以验证与风险因素相关性的一致性.
主要成果:
- 在HP中没有发现PRS对与情绪相关的大脑活动的直接影响.
- 在左腹侧前额皮质 (VLPFC) 中观察到PRS和ELC之间的显著相互作用.
- 具有较高PRS的个体显示出更高的VLPFC活性,特别是在ELCs的存在下. 在SCZ患者中,VLPFC反应比HP更强.
结论:
- 与情绪相关的VLPFC反应与从遗传和非遗传风险因素到SCZ的途径有关.
- 这一发现表明,我们对SCZ的中间表型有了更新的理解,包括早期的非遗传风险因素.
- VLPFC可以作为一个关键的神经生物学标志物,受SCZ发育中的遗传倾向和环境因素相互作用的影响.
更多相关视频
相关概念视频
Biological Causes of Schizophrenia
57
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
57
Psychological and Sociocultural Causes of Schizophrenia
89
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
89
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
648
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
648
Human Genetics
570
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
570
Schizophrenia
80
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
80
Socioemotional Development during Infancy
55
Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
Primary Temperament Types
55


