雌激素,脂肪组织和环境暴露会影响整个生命周期的肥胖和糖尿病
Olgert Bardhi1, Pallavi Dubey2, Biff Franklin Palmer3
1Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
The Proceedings of the Nutrition Society
|February 2, 2024
概括
内源性雌激素调节关键的代谢功能. 外源植物雌激素和异源雌激素也会影响健康,但它们的风险和益处需要仔细研究和减少暴露.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 环境健康 环境健康
背景情况:
- 内源性雌激素 (雌醇,雌激素,雌醇) 对于代谢调节至关重要,包括胰岛素敏感性和脂质稳定.
- 雌激素受体 (ERs) 调解内源性雌激素的作用.
- 外源性化合物如植物性雌激素 (植物性) 和合成的雌激素 (合成) 可以与ER相互作用,可能破坏内分泌功能.
研究的目的:
- 总结内源性雌激素在代谢调节中的作用.
- 讨论植物雌激素和异雌激素对生物系统的影响.
- 突出外源性雌激素的机制,益处,风险和研究缺口.
主要方法:
- 文献综述和对内源性,植物性雌激素和异性雌激素现有研究的综合.
- 对它们与雌激素受体 (ERs) 相互作用的分析.
- 讨论不同生命阶段对健康的影响.
主要成果:
- 内源性雌激素对于维持新陈代谢平衡至关重要.
- 植物雌激素提供潜在的益处,但由于上下文依赖的影响,需要谨慎解释.
- 异性雌激素对健康构成重大风险,包括内分泌干扰,癌症,不孕症和代谢障碍,因为它们的持久性和干扰内源性激素.
结论:
- 了解内源性和外源性雌激素之间的复杂相互作用对于评估健康后果至关重要.
- 需要进一步的研究来阐明机制,并减轻与植物雌激素和异性雌激素暴露相关的风险.
- 尽量减少对有害的异性雌激素的暴露对公共健康至关重要.
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