在澳大利亚随机对照试验中使用关联的行政数据:一个范围审查
Salma Fahridin1, Neeru Agarwal1, Karen Bracken1
1NHMRC Clinical Trials Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.
Clinical trials (London, England)
|February 2, 2024
概括
在澳大利亚临床试验中重新利用行政数据可以提高效率,但也面临着挑战. 关键的限制包括参与者的同意和数据访问,尽管扩展数据集可能会改善未来的使用.
科学领域:
- 临床试验 研究 研究 临床试验 临床试验
- 医疗保健服务研究 医疗服务研究
- 数据科学数据科学数据科学
背景情况:
- 对于高效和成本效益的临床试验的需求日益增长.
- 越来越多的人对利用常规收集的行政数据进行研究感兴趣.
- 需要了解澳大利亚随机对照试验 (RCT) 中管理数据的应用.
研究的目的:
- 对如何以及为什么在澳大利亚RCT中使用行政数据进行范围审查.
- 确定在RCT中使用行政数据的优点和局限性.
- 探索阻碍和促进RCT访问行政数据的障碍.
主要方法:
- 搜索到2022年11月的澳大利亚行政数据的RCT数据库.
- 包括2000年1月至2022年11月间发表的研究.
- 两个独立的审稿人选了标题,摘要和全文,并提取了数据.
主要成果:
- 包括来自36个RCT的41篇文章,通常与政府索赔,住院和出生/死亡登记处进行链接.
- 主要用途是确定疾病结果,生存状况和跟踪医疗服务使用情况.
- 实现了高连接率 (>90%),但同意和撤回是限制;优势包括数据可靠性和长期跟踪.
结论:
- 链接的行政数据需要详细的知识,并面临时间延迟,造成研究障碍.
- 缺乏初级保健数据的访问是一个障碍,但链接医疗保健数据集的扩展正在改善可访问性.
- 增加行政数据的使用对未来的RCT行为和设计有影响.
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