目前的证据表明,在小卵性前列腺癌的局部治疗
Spyridon P Basourakos1, Grant Henning, R Jeffrey Karnes
1Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.
Current opinion in urology
|February 2, 2024
概括
针对小卵性前列腺癌 (OMPC) 的局部治疗方法显示出有前途. 低温疗法,辐射和细胞还原性前列腺切除术为管理前列腺癌的中间阶段在它进展之前提供了新的选择.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 转移性前列腺癌 (PCa) 是一种致命的疾病.
- 低基质转移性PCa (OMPC) 是局部转移性疾病和广泛转移性疾病之间的中间阶段.
- 越来越多的趋势是将局部治疗纳入OMPC的早期管理.
研究的目的:
- 审查目前关于OMPC局部治疗选择的证据.
- 在疾病进展之前讨论局部疗法在OMPC管理中的作用.
主要方法:
- 对OMPC中局部治疗选择的现有证据的审查.
- 专注于主要疾病的局部治疗,而不是转移导向疗法 (MDT).
主要成果:
- 整个腺体冷疗法,有或没有ADT和化疗,显示出有限的有希望的结果.
- 在临床试验中,与ADT结合的放射治疗已经证明改善了无进展生存率.
- 细胞还原性前列腺切除术 (CRP) 与ADT结合显示出有希望的发现,主要来自回顾性研究,并进行正在进行的随机对照试验.
结论:
- OMPC是一种独特的疾病类别,具有特定的治疗意义.
- 由于缺乏可靠的临床数据,OMPC的治疗选择存在争议.
- 需要进一步的长期研究来确定OMPC患者将受益于局部治疗.
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