超加工食品,疾病活动和性结肠炎的炎症:曼尼托巴人生活在IBD研究中
Kathy Vagianos1,2, Casandra Dolovich1,3, Kelcie Witges1
1University of Manitoba IBD Clinical and Research Centre, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
The American journal of gastroenterology
|February 2, 2024
概括
过度加工食品 (UPF) 的高摄入量与性结肠炎患者更活跃的疾病和炎症有关. 减少UPF可能有助于控制炎症性肠病 (IBD) 的症状和炎症.
科学领域:
- 胃肠病学和营养科学 胃肠病学和营养科学
- 饮食模式与疾病
- 炎症性肠道疾病研究研究
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),影响全球众多成年人.
- 饮食因素,特别是超加工食品 (UPF) 消费,越来越多地被审查在慢性疾病管理中的作用.
- 了解UPF对IBD活动和炎症的特定影响对于开发有效的饮食干预措施至关重要.
研究的目的:
- 调查超加工食品 (UPF) 消费与症状性疾病活动之间的关联.
- 为了检查UPF摄入量和IBD成年人肠道炎症标志物之间的关系.
- 为了区分克罗恩病 (CD) 和性结肠炎 (UC) 患者之间的这些影响.
主要方法:
- 被诊断为CD或UC的参与者从曼尼托巴生活在IBD研究中招募.
- 活动性疾病和肠道炎症分别使用验证的症状清单和便calprotectin水平进行评估.
- 饮食摄入量,包括UPF消费 (根据NOVA系统分类为三分之一),使用哈佛食品频率问卷进行评估;多重线性回归被用于分析.
主要成果:
- 在性结肠炎 (UC) 患者中,更高的UPF消耗 (第三次与第三次1) 与活跃疾病和肠炎的增加相关 (P <0.05).
- 在对共变量进行调整后,较低的UPF摄入量与UC中较少的活跃疾病发作 (β = -7.11,P = 0.02) 和肠道炎症 (β = -0.95,P = 0.03) 相相关.
- 在克罗恩病 (CD) 患者中,没有观察到UPF消费与疾病活性或炎症之间的显著关联.
结论:
- 超加工食品 (UPF) 消费可能成为症状性疾病活动和肠道炎症的预测因素,特别是在性结肠炎 (UC) 患者中.
- 减少UPF摄入量成为减轻炎症性肠病 (IBD) 患者更广泛的人群中症状和炎症的潜在饮食策略.
- 进一步的研究可能会根据UPF消费模式探索针对不同IBD亚型的食建议.
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