慢性肺部全移植功能障碍的诊断和管理
Geert M Verleden1, Jeroen M H Hendriks2,3, Stijn E Verleden1,2,3
1Department of Pneumology.
Current opinion in pulmonary medicine
|February 2, 2024
概括
慢性肺异位移植功能障碍 (CLAD) 是肺移植后的一种严重并发症. 最近的进展改善了诊断和风险识别,但需要更多的研究才能找到有效的治疗方法.
科学领域:
- 肺部病理学 肺部病理学
- 移植医学 移植医学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性肺移植异位功能障碍 (CLAD) 是肺移植后的主要危及生命的并发症.
- 最近基于肺功能测试和CT扫描的CLAD表型的分类使人们对其诊断,风险因素和管理产生了新的兴趣.
研究的目的:
- 审查CLAD表型化肺功能测试和胸部CT扫描的最新进展.
- 为最近在确定CLAD临床风险因素和生物标志物的进展提供全面的概述.
- 审查CLAD的新型预防和治疗治疗策略.
主要方法:
- 文献综述,重点关注CLAD诊断,危险因素和治疗方面的最新进展.
- 分析肺功能测试和胸部CT扫描在CLAD表型化中的实用性.
- 关于组织和支气管支气管支气管洗液中的生物标志物的研究综合.
主要成果:
- 肺功能测试和CT扫描对于CLAD诊断和表型化至关重要,尽管存在局限性,特别是在先前存在异位移植功能障碍的患者中.
- 鉴定临床风险因素和特定生物标志物 (组织/BAL) 对于及时诊断和管理至关重要.
- 新的CLAD预防和治疗策略正在出现.
结论:
- 尽管取得了重大进展,但CLAD仍然是肺移植的关键挑战.
- 对风险因素,生物标志物和治疗方法的持续研究对于改善肺移植接受者的结果至关重要.
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